The booster phenomenon occurs during TB skin testing when an individual who is tested many years after becoming infected with tuberculosis has a falsely negative (non-reactive) skin test initially, followed by a positive reaction to a second TB skin test given from one week up to a year later. This occurs because the first test boosts the immune response.
Two-step testing is used in screening programs in order to tell the difference between a boosted reaction and a reaction due to a recent infection. Typically, the second test follows the first by one to three weeks. If the first is negative and the second is positive, it is felt that this most likely represents a past infection with a booster phenomenon rather than a recent infection.
The difference between a recent infection and a booster phenomenon is important for understanding the risk of developing active tuberculosis disease. Individuals infected with tuberculosis have a 10% lifetime risk of developing active disease. About one-half of that lifetime risk occurs in the first 2 years following infection. Individuals with a recent infection are strongly advised to have INH therapy (assuming that their chest x-ray is normal). If INH is refused or contraindicated, the individual needs to be followed with a repeat chest x-ray at least every 6 months for two years, along with chest x-rays during any prolonged respiratory illness.
Henry J. Kahn, M.D.
Director, UCSF Student Health Service
IMMUNIZATION & TB TESTING (all documents including immunization records and lab sheets with titer values are required)
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REQUIREMENTS |
DESCRIPTION |
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Hepatitis B |
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Varicella |
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Measles |
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Mumps |
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Rubella |
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TB Skin Testing |
OR For people who have had annual TB tests
OR
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| Flu Shot | Verification of the annual Flu shot or refusal to have the shot is required by all hospitals. |
This information was taken from the USCF Student Health Services Immunization Requirements and adapted to fit Chabot College Requirements.
6/27/2005